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5 Conclusion Kinetic modeling and Metabolic Control Analysis allowed the identification of complex I as a promising target for developing therapeutic strategies to selectively inhibit cancer cell proliferation due to its higher flux control on the Krebs Cycle pathway

Shmidov Y, et al

10.1016/j.celrep.2023.112324 Cell Rep

( + supplementation activates Sirtuin 2 (SIRT2), enhancing the reciprocal inhibition of forkhead box O1 (FOXO1) and PPAR- to inhibit adipocyte differentiation and induce fat loss

For evaluation of in vivo tumor growth, a total of 6 10 5 cells (resuspended in 50 L DMEM medium and 50 L Matrigel) were subcutaneously injected into the flank of mice

and Lozano J.A