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Symptoms such as chest pain, severe palpitations, or dizziness require urgent evaluation

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Additionally, studies have not consistently demonstrated a benefit from taking B12 or folic acid supplements in those with vitiligo who do not have these deficiencies

Moreover, it is prohibited for pregnant women, those in the lactation period, and patients with severe chronic diseases

In contrast, in the positive spectra, no molecular ions of hydrangea blue-complex and other complexes with copigments were observed, and only a potassium adduct of 2 ([ 2 + K] + ) was detected at m/z = 393 (Fig