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doi: 10.3390/ijms22137138 114 SaeedNHamzahIHAl-GharrawiSAR

FIGURE 4 5.2 Ferroptosis and DOR Abnormalities in iron metabolism are associated with various degenerative diseases, and granulosa cells, oocytes, and their supporting cells in the ovary are particularly sensitive to OS (Stockwell et al., 2017)

157 This releases cytochrome c and apoptogenic factors such as AIF, Smac/Diablo, and endonuclease G, initiating apoptosome formation and caspase (-9, -3, -6, and -7) activation

For the 1 -AR, two common polymorphisms exist at amino acid positions 49 and 389

Also, knockdown of CD44 strongly prevented clonal formation and inhibited tumorigenicity in a xenograft model, concluding that CD44 had a potential to be a CSC marker for colorectal cancer (CRC)

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