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Many studies have shown that once the mature Texh population is formed, these cells cannot be de/re-differentiated into the Teff/Tmem states 15, 31, 274, 276, 277, 278

7, e35458

Prebiotics demonstrate ubiquitous presence within natural botanical matrices and, functioning as precision nutritional intervention modalities, exhibit unparalleled advantages in CKD populations confronting dietary protein restriction challenges (Tsai et al., 2019)

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TNF-a promotes cell proliferation, as well as apoptosis and necroptosis of the cardiomyocytes in response to its cell signalling mechanisms related to the dilated cardiomyopathy condition (89)

RCTs with rigorous lifestyle control [e.g., standardized physical activity protocols] are needed to confirm causal relationships
