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Description
Metformin ameliorates peripheral neuropathy in diabetic rats by downregulating autophagy via the AMPK pathway
The rival will present further data for oral candidate orforglipron at EASD from the Phase III ATTAIN-1 trial on Wednesday

Saiz-Rodrguez M, Almenara S, Navares-Gmez M, Ochoa D, Romn M, Zubiaur P, Koller D, Santos M, Meja G, Borobia AM, Rodrguez-Antona C, Abad-Santos F (2020) Effect of the most relevant CYP3A4 and CYP3A5 polymorphisms on the pharmacokinetic parameters of 10 CYP3A substrates

Schwentner, I

LKB1, a tumor suppressor, is a major mammalian AMPK kinase in the liver that activates AMPK by phosphorylating the Thr172 residues of AMPK subunits

Very similar to the Super Shotgun in Doom II
