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Nature 450 , 11901194 (2007)

Diverse mechanisms of cisplatin sensitivity/ resistance involve complex processes including drug transport, efflux of drug, detoxification of the drug, response to DNA damage, increased DNA repair, epigenetic changes and autophagy

Higher initial cost due to the complexity of the molecule

These results indicated that GSTP hampered the association of HMGB1 with cPKC, but not cPKC translocation

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One of the most common polymorphisms, affecting 20% to 50% of certain populations, is an absence of the GSTM1 gene ( GSTM1 -null), which decreases detoxification ability among other possible outcomes [36]