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Conditions like neurodegenerative disease, insulin resistance, endocrine imbalances, liver and kidney disease are intimately linked to metabolic disorders or inflexibility and to mitochondrial dysfunction
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doi: 10.1053/j.gastro.2006.10.004
AIP in particular presents an attractive opportunity for liver-targeted gene therapy because only a few functional hepatocytes expressing HMBS are needed to metabolize ALA/PBG in order to avert acute attacks
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At this time, the bodys demand for thyroid hormones increases, and the small amount of iodine stored in the gland is consumed more quickly without being replaced, resulting in a more rapid loss of thyroid status
