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Natural or synthetic compounds similar to CR, the so-called CRMs: they have molecular, cellular, biochemical, and physiological effects similar to CR, without dietary restriction, and are a class of chemicals with potential life-prolonging effects that act through different pathways

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doi: 10.1038/s41591-022-02017-5 82 TianDSQinCDongMHHemingMZhouLQWangWet al

1 Moreover, the high failure rate of clinical trials makes it difficult to effectively validate hypotheses, possibly attributed to the coexistence of multiple theories (which will be detailed in subsequent sections)

Sustained AhR activity programs memory fate of early effector CD8+ T cells

Other enzymatic cleavages have been developed, but the two listed here will serve to illustrate their application