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Moreover, in a very recent review concerning overthecounter (OTC) supplements, such as herbs, vitamins, and nutritional supplements for the treatment of male infertility, one more point is stressed by the authors as many OTC studies fail to control the baseline dietary intake by patients of the analyzed substances the authors caution against the widespread use of the OTC supplements above and beyond the recommended daily allowance in order to avoid triggering any possible side effects [58]

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Although reprogramming has historically used viral vectors, recent advancements in microRNA technology has led to the development of alternative transcription factor delivery methods that have been reported to increase the conversion efficiency in vitro and in vivo from somatic cells into functional dopaminergic neurons and ameliorate motor symptoms in a model of PD

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Nevertheless, randomized clinical trial on these procedures have shown contradictory results, and thus, these procedures are not systematically recommended

doi: 10.1055/a-2191-9969 [DOI] [PMC free article] [PubMed] [Google Scholar] 59.Kaneto H, Matsuoka TA, Nakatani Y, et al