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Third, the TrkB inhibitor ANA-12 reduced the beneficial effects of ketamine on cisplatin-induced kidney injury and depression-like behaviors by suppressing the TrkB and ERK-CREB signaling, especially by inhibiting the phosphorylation of TrkB, ERK, and CREB in the kidney and PFC

In summary, we focus on iron death in a neurological context, the key regulatory role of Nrf2 on iron death, and discuss that the close link between Nrf2 and ferroptosis is of clear and important significance for understanding the mechanism of ND based on OS, characterized by neuronal loss and mitochondrial dysfunction, and represented by AD, PD, HD, and ALS, and point out the bright prospect of Nrf2-targeted therapy in the diagnosis and treatment of ND

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Gut microbiota alleviates intestinal injury induced by extended exposure to light via inhibiting the activation of NLRP3 inflammasome in broiler chickens

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