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IUPHAR review - glucagon-like peptide-1 (GLP-1) and substance use disorders: an emerging pharmacotherapeutic target

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For example, engineered Escherichia coli Nissle 1917 (EcN) co-expressing anti-PD-L1 and anti-CD9 nanobodies (EcN-Nb) and modified with ICG-loaded zinc-based MOFs to generate EcN-Nb-ZIF-8CHO-ICG (ENZC), can specifically release nanobodies in response to NIR radiation thereby targeting tumor-derived exosomes (TDEs) to alleviate immunosuppression, such as reshaping TAMs to the M1 state and activating more effective and cytotoxic T lymphocytes, ultimately inhibiting tumor proliferation and metastasis (229)

Sleep deprivation elevates the production of NO and RNS, which catalyze the nitrosylation of crucial proteins, including the N-ethylmaleimide sensitive factor (NSF) and postsynaptic density-95 (PSD-95)