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These markers may be associated with neurodevelopmental vulnerability in some children and are best interpreted with symptoms, history, and labs

In contrast, in diseases characterised by mitochondrial dysfunction and bioenergetic failure (often reflected by reduced FDG-PET signal), elevated iron may instead represent a compensatory response to functional iron deficiency rather than a pathogenic surplus

It leads to the activation of the MAPK pathway, which conditions the uncontrolled proliferation of tumor cells (226)

[DOI] [PMC free article] [PubMed] [Google Scholar] Michelet L., Zaffagnini M., Vanacker H., Le Marchal P., Marchand C., Schroda M., Lemaire S.D., Decottignies P