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However, using other peptidic ([Leu 5 ]- and [Met 5 ]-enkephalins and UFP-512 ([H-Dmt-Tic-NH-CH(CH 2 -COOH)-Bid])) and non-peptidic (SNC-80 ((+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethyl-benzamide) and ARM-390) ligands we didn't confirm such assumption but our data rather suggest that DOR selective agonists promote profound desensitization compared to non-selective ligands (Marie et al., 2003a

This assessment was conducted using a polynomial quadratic model, which demonstrated an adequate precision of 11.2 and a reasonable disparity between the predicted R 2 (0.7078) and the adjusted R 2 (0.6387), with the difference being less than 0.2

doi:10.4103/1673-5374.316990 Sikiric P, Seiwerth S, Brcic L, et al

This allows the peptides to penetrate deeply, speeding up the healing of acne lesions, reducing inflammation, and preventing future breakouts

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ISSN 0307-4412