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FarhatZHershbergerPAFreudenheimJLMammenMJHageman BlairRAgaDSet al

Disease onset is often preceded by a prolonged preclinical phase, during which subclinical immune alterations, including the presence of autoantibodies and cytokine imbalances, may be detectable years before symptoms occur

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It plays an important role in maintaining tissue homeostasis and coordinating immune and defense functions ( Under specific conditions, cells can switch from apoptosis to ferroptosis, a transition that enhances cellular sensitivity to apoptotic signals ( 4.2 Ferroptosis and necroptosis The distinction between ferroptosis and necroptosis lies mainly in their dependency mechanisms and triggering factors