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doi:10.1016/s0378-8741(00)00263-4 Liu J, Yang F, Ye LB, et al

Mechanistically, the literature often points to pathways tied to: angiogenesis and vascular signaling (VEGF-related pathways), nitric oxide signaling, and cell migration / fibroblast activity involved in tissue remodeling

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[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Nuttall SL, Martin U, Sinclair AJ, Kendall MJ

Insulin receptor null mice (Irs1/) had longer lifespan and displayed resistance to a range of age-sensitive biomarkers of ageing (Selman et al., 2008)

These may include: Pain or irritation at the injection site
