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[DOI] [PMC free article] [PubMed] [Google Scholar] 252.Penugonda S, Ercal N

However, the therapeutic utility of doxorubicin is undermined by its dose-dependent cardiotoxicity, possibly arising as a result of futile redox cycling, with NADH dehydrogenase within the mitochondria proposed as the most likely site of anthracycline reduction 9,10

However, factors like overall health, metabolism, and post-therapy care significantly influence the treatments effectiveness and outcome

Hydrogen peroxide has a longer half-life than superoxide, and unlike superoxide, hydrogen peroxide can transfer across lipid membranes by either diffusion or transport through channels, such as aquaporins (38)

Liver health Antioxidant deficiencyincluding a lack of glutathionecan exacerbate cell death in the liver and lead to fatty liver disease

454 Such damage can be transmitted to astrocytes and trigger more inflammatory factors to activate inflammatory responses