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[,] The mechanisms and targets of cellular oxidative stress upon the introduction of heavy metals are shown in a simplified manner in Figure 1

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However, 2D co-cultures often consist of only 2 cell types due to spatial constraints and limitations in nutrient diffusion, thereby failing to capture the full cellular complexity of the adipose microenvironment

Increased expression of GR is noted during stress conditions, as was observed for various plant species (Gill et al

Lee, S., Doxey, A

Glutamate excitotoxicity is thought to play a significant role in several forms of neurodegenerative disease, leading to neuronal damage and cell death through both apoptotic and nonapoptotic mechanisms