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Generally, these new strategies should be directed towards diseases with significant unmet clinical needs, including cases that have relapsed or are resistant to current treatments, as well as rare (orphan) diseases

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Thromb Haemost 87(4):728734 Fukumoto K, Fogaa MV, Liu R-J, Duman C, Kato T, Li X-Y, Duman RS (2019) Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2R,6R)-hydroxynorketamine

Oxygen atoms from carboxyl groups complete the chelation