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Research suggests that high doses can lead to potential side effects, including: Gastrointestinal Issues: High doses may cause nausea, diarrhea, and abdominal discomfort
10.1186/s40425-019-0650-9 J

Although neither the mechanism nor the implications of these changes are well defined, the high GSH content makes cancer cells chemoresistant, which is a major factor that limits drug treatment

Twin Res Hum Genet 2009, 12: 246253

The relatively rapid half-turnover time of glutathione, 65 and 96 h respectively in rat and human red cells 4,7 , suggests that this mechanism plays some part in their metabolic economy

The superior influence of combination between glutathione and soil amendments specially the hydrogel polymer was crystal clear, not only under the well-watered condition but also under the moderately water-stressed and severely water-stressed conditions
