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stiffness and resistance to limb movement caused by increased muscle tone and/or an excessive and continuous contraction of muscles, which may be uniform (lead-pipe rigidity) or ratchety (cogwheel rigidity), and which may be associated with joint pain

Reference Ulrich, Kathrin, and Ursula Jakob

RSL3 binds to the nucleophilic active site of GPX4, and then reduces the expression level of GPX4 most effectively through chloroacetamide moiety (Jelinek et al., 2018), thus inactivating GPX4, producing lethal ROS accumulation and inducing ferroptosis