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In summary, our study primarily investigated the beneficial effects of GHK-Cu in UC, using a DSS-induced colitis mouse model and an in vitro co-culture system, suggesting that GHK-Cu may exert anti-inflammatory properties and its role in facilitating the repair of UC by regulating SIRT1/STAT3 signaling pathway

However, in inflammatory models, trained immunity may aggravate disease, for instance, in dextran sulfate sodium-induced colitis, Mincle-deficient mice displayed milder pathological symptoms, indicating that trained immunity contributes to the pathology of inflammatory bowel disease (142)

Copper tripeptide (GHK-Cu) is a tripeptide

Know what you are dealing with before choosing a treatment approach

[PMC free article: PMC3174853] [PubMed: 21593511] 41