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doi: 10.1073/pnas.1820870116

2.8 Animal studies on the application of probiotics and fecal transplantation In this study, we subsequently conducted animal trials to validate the hepatotoxic effect induced by emodin via intestinal tract

The most effective approach is often whats called an orthomolecular approach
Use 1 to 2% concentrations rather than chasing the highest number

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