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Research indicates that BIPN may arise from the activation of the RAGE/STAT3 signaling pathway in the dorsal horn, which is driven by the accumulation of methylglyoxal

Lancet 389:1756-1770, 2017

Rounds T., Straus S

As a molecule that occurs naturally, LA can be synthesized internally in the mitochondria in small quantities from octanoic acid through the action of LA synthase (LASY) [25]

As a result, there has been significant interest in developing new and more effective treatments for PCOS
