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doi: 10.1200/JCO.21.01992, PMID: [DOI] [PubMed] [Google Scholar] 177

The trajectory graphs (Additional file 5, Additional file 6, Additional file 7) of all varying metabolites simultaneously highlight differences in levels and trajectories

P 0.1, arachidonic acid metabolism, tryptophan metabolism, the TCA cycle, taurine and hypotaurine metabolism, and glycerophospholipid metabolism were identified as the significantly relevant metabolic pathways for this mechanism, and these pathways are important for NAFLD

4 A decade of progress: novel antifungal drugs targeting resistance The main mechanism of antifungal action lies in inhibiting essential molecules, such as ergosterol (azole class) or 1,3--D-glucan (echinocandins), or by binding to ergosterol (polyene class), leading to the formation of pores and altering the integrity and permeability of the cell membrane, thereby affecting the membrane or fungal cell wall

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