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As the purpose of the intra-luminal guidance is to direct the axon growth cone across the gap, once the first axons have bridged the gap, the presence of intraluminal guidance is no longer necessary and its degradation provides more space to fill by the native ECM [51]

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Taking a sample of the tissue from the esophagus through an endoscope only slightly lengthens the procedure time, causes no discomfort and rarely causes complications
