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A preliminary study evaluating diabetic peripheral neuropathy has demonstrated that targeted supplementation with these active B-vitamins (along with pyridoxal 5'-phosphate) can actually increase epidermal nerve fiber density, meaning the nerves physically begin to regrow and heal, leading to a reduction in pain and paresthesia

Comparing outcomes from a localized SubQ injection (lumbar/glute) versus a distant SubQ injection (abdomen) can yield powerful data on the compound's site-enhancement effects