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This alternative hypothesis proposes arrestin-driven receptor-G protein uncoupling (desensitization) as the mechanism responsible for the loss of morphine's analgesic action, which is in turn exacerbated by receptor failure to internalize and undergo resensitization [38, 39]

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This preference for hydroxocobalamin in many countries is due to its long retention in the body

Integr Cancer Ther 15:205

The most appropriate option depends on the patients treatment goals, medical history, and provider evaluation

Your licensed provider will determine the appropriate dose, frequency, and duration based on your clinical profile