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Reversibility of symptomatic peripheral neuropathy with bortezomib in the phase III APEX trial in relapsed multiple myeloma: impact of a dose-modification guideline

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The regulatory mechanism includes CzcR (response regulator) and CzcS (sensor histidine kinase) as a two-component regulatory system [112,113] (Fig

[DOI] [PubMed] [Google Scholar] [191].Guo H, Ouyang Y, Yin H, et al

Einzig bei Krebserkrankungen mit Metastasen bei einer Gesamtmasse des Tumors von mehr als 100 g knnen hhere Tagesdosierungen als 20 mg/kg Krpergewicht Anwendung finden.As a daily dose, the dose range of 2 to 20 mg / kg body weight is generally recommended, whereby the exact dose depends on the individual circumstances in the context of the disease