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Vitamins and Parkinsons disease In PD, Vit D deficiency has been shown to contribute, not only to the reduction in dopamine levels, but may also be involved in the accumulation of alpha-synuclein (SN), a hallmark of PD pathophysiology (Zhou et al

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But that peripheral-only action means it does not suppress appetite, does not change energy expenditure through central pathways, and does not produce the dramatic caloric deficits that GLP-1 agonists like semaglutide or tirzepatide create

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