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J Immunol 173:28596, PMID: 15210786 DAlessio M, De Nicola M, Coppola S, Gualandi G, Pugliese L, Cerella C, Cristofanon S, Civitareale P, Ciriolo MR, Bergamaschi A, Magrini A, Ghibelli L (2005) Oxidative Bax dimerization promotes its translocation to mitochondria independently of apoptosis

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For acute shoulder injuries causing significant pain, split dosing at 0.25mg twice daily may produce better results than 0.5mg once daily despite the same total amount