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Gene set enrichment analysis of the PC1 loadings showed E2F and MYC targets and mTORC1 pathway genes in the top ten under both normoxic and hypoxic conditions, with hypoxia and glycolysis genes under normoxic conditions and oxidative phosphorylation, and epithelial mesenchymal transition genes under hypoxic conditions (Supplementary Table 4)

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10.1089/ars.2016.6866 10.1089/ars.2016.6866 [DOI] [PubMed] [Google Scholar] Yu YP, Yu G, Tseng G et al (2007) Glutathione peroxidase 3, deleted or methylated in prostate cancer, suppresses prostate cancer growth and metastasis

As additionally demonstrated in (Figure 9), in vivo imaging confirmed the favorable biodistribution of BMI and its strong TME-responsiveness in MRI, highlighting its accumulation and activation within the tumor