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Med 23 , 120127 (2017)

The enzymes involved are: The biosynthesis of glutatione in cells is accomplished by six enzymes found on the plasma membrane and in the cytosol from the precursor amino acids Glu, Cys, and Gly

doi: 10.1002/pro.3691 127 ZhaoXZhuYHuJJiangLLiLJiaSet al

Glutathione is also a cornerstone of the detoxification process

The 5-formimino-THF is then converted to N 5 , N 10 -methenylene-THF (5,10-methenylene-THF) via the cyclodeaminase activity of the complex with glutamate and ammonium ion as the other products

It is interesting to note that glutaredoxins (Grx12) also utilize GSH to reduce protein intra/inter-disulfides (PS 2 or protein-glutathione disulfide [PSSG]) into protein sulfhydryl groups (-SH) (7, 8) (Fig