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Description
The E3 ubiquitin ligase Trim63 (also known as MuRF1) can regulate the activity of key enzymes involved in fatty acid oxidation (FAO), such as CPT1A and ACOX1, by affecting the activity of peroxisome proliferator-activated receptor (PPAR)
JACC: Adv
10.1158/1535-7163.MCT-03-0266 [DOI] [PubMed] [Google Scholar] Xiao D., Singh S
This is consistent with the observation that capsid proteins obtained from BSO-treated cells can still associate with RNA to form 150S, albeit unable to produce mature virion
Kim et al., 2002
The design idea is that hitting all three pathways with one molecule may do more than hitting one or two
