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Navid, F., Chen, L., Bowness, P

[DOI] [PMC free article] [PubMed] [Google Scholar] 203

The suppression of mitophagy not only reduces the formation and degradation of autophagosomes but may also trigger cellular stress responses, such as endoplasmic reticulum (ER) stress and oxidative stress, which can further affect the expression and activity of antioxidant enzymes

Since rare diseases are almost always synonymous with high unmet needs, these therapies collected a record number of coveted FDA designations, especially orphan drugs (31), priority reviews (26), fast-track (16), and breakthrough therapy (12)

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doi: 10.3760/cma.j.issn.2095-4255.2017.11.019 116