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FIGURE 2 NAD + can act as a cosubstrate for sirtuins (SIRT) (Verdin, 2015), class III histone deacetylase enzymes whose activity is dependent on NAD + levels (Tang, 2016

Cytoplasmic polyadenylation element-binding protein 3 (CPEB3) also regulates stress-resilient behavior in PTSD

Common signs include: Feeling wired at night but exhausted in the morning Trouble falling asleep or staying asleep Sugar, salt or caffeine cravings Weight gain around the midsection Anxiety, low mood, or irritability Frequent infections or slow wound healing Brain fog and poor concentration While the term adrenal fatigue is often used in popular wellness language, its more accurate to describe this as HPA axis dysfunction where the signalling between brain and adrenal glands becomes impaired