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11 There are two CTR members in humans, CTR1 and CTR2

Peer review under the responsibility of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences

ROS can lead to NLRP3 activation through binding to thioredoxin-interacting protein (TXNIP) binding following thioredoxin oxidation (Zhou et al., 2011)

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Methionine deprivation can cause a global decrease in histone methylation [41,45] and models of B12 deficiency have also been shown to decrease the methylation level of proteins [46,47] (Figure 2A)

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