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Since red meat is particularly rich in LC [69], dietary intervention in healthy adults, indicated a significant increase in plasma and urine TMAO levels following 4 weeks of the red meat-enriched diet [70]

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2017 meta-analysis: Five RCTs in 631 adults with insulin resistance showed that 23 g/day L-carnitine for 4 weeks to 12 months improved insulin resistance, with benefits at 12 months exceeding those at 3 months [3][42]

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Clinical relevance of skeletal muscle abnormalities in patients with cirrhosis

In sex-specific analysis, as for l-carnitine, genetically predicted acetyl-carnitine was also related to higher risk of CAD in men (OR 1.09, 95% CI 1.02 to 1.16) but not in women (OR 1.00, 95% CI 0.92 to 1.09) (Additional file 2: Fig