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MCCOSMETICS Prof

As an example, it has been demonstrated that a mutation (S662G) in PER2, which is known to be responsible for the familial advanced sleep phase syndrome, increased resistance to apoptosis and E1A- and RAS-driven oncogenic transformation, as well as affected tumorigenesis in p53 R172H/+ mice, with a cancer-sensitized genetic background 38

Clinical trials involving over 900 human subjects across six randomized, double-blind, placebo-controlled studies confirmed the safety profile