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An assortment of epidemiological and clinical studies have stated glucose and lipid metabolism alterations, insulin resistance, and central obesity as predominant factors for the development of MetS [38, 212]

Inconsistent or vague diagnoses often trigger payer requests for additional records or result in outright denial

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The C9ORF72 repeat expansion may act as a risk factor

Researchers believe that increased cAMP levels may activate protein kinase A (PKA), which appears to be a key intracellular signaling molecule

[DOI] [PubMed] [Google Scholar] 109.Schwartz JP, Jungas RL