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Pan et al, in a in vivo study performed with transgenic mice, have shown that chronic treatment with benfotiamine, a thiamine derivate with better bioavailability, enhanced the spatial memory and reduced both amyloid plaque numbers and phosphorylated tau levels, suggesting that this thiamine derivative may be useful in clinical Alzheimers disease treatment, although others thiamine derivatives do not showed the same results ( Table 2 )

Side effects like swelling, joint pain, or hormone changes are also possible

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No control group, single-center, limited statistical power

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Lack of intrinsic factor is most common in older people and is usually associated with an autoimmune disease known as pernicious anaemia