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The review process will follow the process previously used during the Safety Net appeals at the outset of DSRIP

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Other than liver tumors, no plausible MOA has been hypothesized for the other tumor types associated with exposure to 1,4-dioxane

In NSCLC patients on ICIs, elevated plasma taurolithocholic acid (TLCA) and glycochenodeoxycholic acid (GCDCA) correlated with improved outcomes

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Materials and methods Generation of adipocyte-specific SIRT3 overexpression mice The environmental conditions in the animal facility were: temperature range of 2123 C, humidity range of 4050%, 12 h light/dark cycle, and free access to food and water