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Indian Journal of Chest Diseases and Allied Sciences

PMID: 23912329

Ferroptosis nanomedicine: clinical challenges and opportunities for modulating tumor metabolic and immunological landscape

To date, 14 studies have investigated GSH, GSSG, GSH/GSSG and/or tGSH levels in the plasma of healthy adults (Andriollo-Sanchez et al., 2005, Chillemi et al., 2005, Giustarini et al., 2006, Hernanz et al., 2000, Houze et al., 2001, Jones et al., 2002, Kretzschmar et al., 1991, Maciejczyk et al., 2019, Michelet et al., 1995, Nuttall et al., 1998, Paolisso et al., 1998, Rea et al., 2004, Samiec et al., 1998, Yang et al., 1995), with the majority using HPLC (N = 10, 71%) (Chillemi et al., 2005, Giustarini et al., 2006, Hernanz et al., 2000, Houze et al., 2001, Jones et al., 2002, Michelet et al., 1995, Paolisso et al., 1998, Rea et al., 2004, Samiec et al., 1998, Yang et al., 1995), and the remaining using colorimetry (N = 2, 14%) (Kretzschmar et al., 1991, Maciejczyk et al., 2019), enzyme-rate essay (Nuttall et al., 1998) (N = 1, 7%), and spectrophotometry (N = 1, 7%) (Andriollo-Sanchez et al., 2005) (Table 3)

This represents a limitation for our work and the conclusions that can be drawn from it, particularly for some specific micronutrients for which the oncoprotective or pro-oncogenic role remains unclear

TLR4 (Toll-Like Receptor 4)-dependent signaling drives extracellular catabolism of LDL (low-density lipoprotein) aggregates