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Qiang Li, [email protected] These authors have contributed equally to this work This article was submitted to Inflammation Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Yohimbine also occurs in many other plants such as the quebracho blanco plant of South America

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Because TRP is a Ca 2+ channel activated downstream of phospholipase C, conjecture arose that it might represent the long-sought store-operated Ca 2+ channel (Hardie & Minke, 1993)

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