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Both vitamin D synthesis and tryptophan metabolism are affected by UV exposure, and reduced UV exposure may impair mucosal immunity and induce changes in the gut microbiome 59

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Hereditary or acquired defects in the transport mechanisms are the major cause of l-carnitine deficiency, leading to pathologies such as cardiomyopathy and skeletal muscle myopathy [12,13]

On T1-weighted MRI, an increased signal in the basal ganglia is commonly observed, but those changes lack the sensitivity and specificity required to diagnose HE [227]

Lire larticle P Colombani et al

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