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Therapeutic and preventive potential of plant-derived antioxidant nutraceuticals

doi: 10.1038/sj.cdd.4401181

[DOI] [PubMed] [Google Scholar] 520

6.2 Cervical cancer Retrospective cohort studies demonstrated that metformin use in patients with diagnosed T2DM was associated with a lower risk of cervical cancer (Takiuchi et al., 2017), several studies revealed that metformin treatment decreased cervical cancer-specific and overall mortality in older women with T2DM ( It has been reported that metformin inhibits cell viability, migration, and metastasis and induces cell-cycle arrest, autophagy, and apoptosis in cervical cancer cell lines and cervical cancer xenografts (Xia et al., 2018)

10.1016/S1470-2045(20)30527-1 [DOI] [PMC free article] [PubMed] [Google Scholar] Arango D., Wilson A

The study showed significant increases in intracellular glutathione levels after just 2 weeks of use, as well as demonstrating its ability to support healthy NK cell function and oxidative stress levels.*