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Description
Such an alteration in miRNA-mediated post-transcriptional regulation of gene expression could have a broad impact in cells, including in the negative regulation of ATXN3 expression itself, as the 3 UTR of human ATXN3 is targeted by miRNAs

Haffner CD, et al
Blau N, Hennermann JB, Langenbeck U, Lichter-Konecki U

[10] Clinical studies have reported no harmful effects with chronic daily doses as high as 200 mg (many times the nutritional requirement), indicating a wide safety margin for this vitamin

N.RajaH

10.1016/0006-8993(87)90499-9 137 KondoT.RaffM
