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According to the leaky gut theory, these alterations in gut microbiota may be related to inadequate perfusion to the viscera due to cardiac congestion or impaired ejection capacity in patients with HF, and ischemic edema in the intestine caused by ischemia, which might increase the permeability of the intestinal epithelium (Sandek et al., 2007), thus allowing intestinal macrobiotic and bacterial metabolites to gain access to the circulatory system through the compromised barrier

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More extensive human trials are needed to confirm these preclinical observations, establish optimal dosing, and fully understand its safety profile

Notably, all patients were in the acute phase of PD ( 6090 degrees

10.1038/npp.2011.191 Neuropsychopharmacology 46 Di MonteD

Their hydrophobic segments are adjacent to phospholipid tails, and their hydrophilic segments are adjacent to phospholipid heads and protrude into the fluid adjacent to the membrane (e.g., into the cytosol) ( Figure 5