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Adv Sci (Weinh) (2021) 8:2001308
At least for the mouse GPx-1 gene, a 3 enhancer region with GATA nuclear factor binding sites regulates transcription in erythroid cells, which have a higher rate of expression compared to tissues such as brain (271)

"We have identified a potential early target in the molecular ageing of the brain," the researchers say, "that may be important for the stability of cellular quality control." In the long term, these findings could help us better understand the development of neurodegenerative diseases such as Alzheimer's or Parkinson's, in which disturbances in protein degradation play a central role

131,132 Unfortunately, the long-term effects of acetaminophen exposure on neural development have never been evaluated in humans

Acta 473, 237244

doi: 10.1172/jci.insight.124885 99 Tejera-AlhambraMAlonsoBTeijeiroRRamos-MedinaRAristimunoCValorLet al
