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The B12 component of your compounded formulation becomes even more important at this dose because the gastrointestinal effects that impair nutrient absorption are at their strongest

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[Google Scholar] Mikus D., Sikiric P., Seiwerth S., Petricevic A., Aralica G., Druzijancic N., et al

Best Time to Take B12 for Weight Loss: Evidence and Guidance Vitamin B12 (cobalamin) is an essential water-soluble vitamin vital for red blood cell formation, neurological function, and energy metabolism

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Yes, people with pernicious anemia need vitamin B12 for life