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Additional references Allen 2009 Allen L
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(PubMed) Ou P, Tritschler HJ, Wolff SP

PI3K/AKT signalling, primarily activated by insulin, is crucial for metabolic homeostasis, regulating energy storage and lipid synthesis and breakdown, as well as controlling glucose uptake into adipocytes and other insulin-sensitive tissues, including the promotion of adipogenesis and adipocyte differentiation [56, 57]
In most cases these were mildly to moderately expressed and presented as (blepharo)conjunctivitis or superficial keratitis, which could mostly be sufficiently treated by local ophthalmological therapy without reduction or discontinuation of dupilumab
